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ea0029p753 | Endocrine Disruptors | ICEECE2012

Perinatal exposure to a commercial formulation of glyphosate reduces the mRNA expression and increases the protein content of beta TSH in the pituitary of male offspring.

Romano R. , Souza P. , Nunes M. , Romano M.

Glyphosate is a broad spectrum herbicide that is effective against weeds, especially in association with transgenic glyphosate resistant crop systems, and represents approximately 30% of all herbicides used in agriculture. It was demonstrated that glyphosate has an activity of endocrine-chemical disruptor (ECD) in the reproductive axis, altering the production of testosterone and causing disturbances on the reproductive development of male offspring from dams treated during th...

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ea0029p1333 | Pituitary Basic | ICEECE2012

T3 and T4 rapidly regulate the TSH, FSH and LH α subunit gene expression at posttranscriptional level

Souza P. , Romano R. , Silva F. , Brunetto E. , Nunes M.

Several studies demonstrated that the thyroid hormones (TH) downregulate the transcriptional rate of beta and alpha TSH subunits. Recent data showed that T3 also acts posttranscriptionally reducing the polyadenylation and translational rate of the beta TSH mRNA, when acutely administered to thyroidectomized (Tx) rats. This study aimed to investigate whether similar effects occur for the alpha subunit synthesis after acute administration of T3 or T4</...

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Endocrine Abstracts

Perinatal exposure to a commercial formulation of glyphosate reduces the mRNA expression and increases the protein content of beta TSH in the pituitary of male offspring.

T3 and T4 rapidly regulate the TSH, FSH and LH α subunit gene expression at posttranscriptional level

BiosciAbstracts